Oestrogel 0.06% Gel 80g

Directions

Note: Always follow the instructions in the patient leaflet and from your doctor.

• Dose:

  • Typically 2–4 pumps daily, as advised by GP

• Application:

  • Apply to clean, dry, intact skin of upper arms or thighs

  • Rub in gently and allow to dry

  • Wash hands immediately after use

Storage:

• Store below 25°C

• Do not freeze

• Keep out of reach of children

Ingredients

• Active Ingredient:

  • Estradiol hemihydrate 0.06% w/w (0.75mg per 1.25g pump)

• Key Excipients:

  • Ethanol

  • Carbomer

  • Trolamine

  • Purified water

Side Effects

Common side effects:

• Breast tenderness

• Headache

• Skin irritation at application site

• Nausea

• Menstrual spotting

Serious (rare):

• Blood clots

• Stroke

• Breast or endometrial cancer

Report any unusual bleeding, breast changes, or persistent symptoms to a doctor.

Warnings

• Contraindications:

  • Known or suspected breast cancer

  • Undiagnosed vaginal bleeding

  • History of thrombosis

  • Liver disease

• Pregnancy/Breastfeeding:

  • Not suitable for use during pregnancy or while breastfeeding

• Drug Interactions:

  • May interact with enzyme-inducing medicines (e.g. carbamazepine)

• Monitoring Required:

  • Regular breast exams and blood pressure checks

Oestrogel is a transdermal hormone replacement therapy (HRT) that delivers estradiol, a form of oestrogen, through the skin. It is used to manage symptoms of menopause, including hot flushes, night sweats, mood changes, and vaginal dryness, which occur due to falling oestrogen levels.

This gel-based format offers an alternative to oral HRT, providing direct absorption into the bloodstream and avoiding first-pass metabolism by the liver.

How It Works

Oestrogel contains estradiol hemihydrate, which mimics the natural oestrogen produced by the ovaries. After menopause, oestrogen levels decline significantly, leading to various symptoms that can affect quality of life. When applied to the skin, Oestrogel gradually releases estradiol into circulation, helping to restore hormonal balance and reduce menopausal discomfort.

The transdermal application allows for a steady release of hormone, contributing to more stable blood levels and potentially fewer side effects compared to oral HRT.

Why Choose Oestrogel

Oestrogel is a well-established and popular choice for many women undergoing hormone replacement therapy. It offers several advantages:

Non-oral administration avoids gastrointestinal side effects

Flexible dosing based on severity of symptoms

Effective relief from vasomotor symptoms (e.g. hot flushes)

Convenient and discreet once-daily application

Lower risk of blood clots compared to oral HRT in some cases

Its clear, odourless gel dries quickly and is applied to the upper arms or thighs.

Important Note

Oestrogel should be used exactly as prescribed. For women with an intact uterus, a progestogen must be added to the HRT regimen to protect against endometrial cancer. Regular reviews with a healthcare provider are essential, especially for long-term use. Always wash hands after applying and avoid skin contact with others until the gel has dried completely.