Estradot

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

• Apply one patch to clean, dry, hairless skin (lower abdomen or buttocks)

• Replace the patch every 3 to 4 days (twice weekly schedule)

• Do not apply to breasts or broken/irritated skin

• Rotate application sites to avoid skin irritation

• Store below 25°C

• Keep in original packaging

• Keep out of reach of children

Ingredients

Active Ingredient:

• Estradiol (25mcg/50mcg/75mcg/100mcg per 24 hours depending on variant)

Other Ingredients:

• Acrylate copolymer adhesive

• Silicone adhesive

• Polyester backing film

• Release liner (to be removed before application)

Side Effects

Common side effects may include:

• Skin irritation at patch site

• Headache

• Breast tenderness

• Nausea

Serious (rare) side effects:

• Blood clots

• Stroke or heart attack

• Breast or endometrial cancer

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not use Estradot if you have a history of breast cancer, blood clots, stroke, liver disease, or unexplained vaginal bleeding. Use with caution in patients with risk factors for cardiovascular disease. Not for use during pregnancy. Regular monitoring by a healthcare provider is essential.

Estradot is a transdermal hormone replacement therapy (HRT) used to manage moderate to severe symptoms of menopause due to oestrogen deficiency. These include hot flushes, night sweats, mood swings, and vaginal dryness. Suitable for postmenopausal women, Estradot helps restore hormonal balance using bioidentical oestradiol delivered directly into the bloodstream.

How It Works
Each Estradot patch contains a specific dose of oestradiol, which is released steadily through the skin and absorbed into systemic circulation. This avoids first-pass metabolism by the liver and provides consistent hormone levels, reducing fluctuations and improving symptom control. Estradot addresses oestrogen deficiency by replenishing hormone levels, helping regulate thermoregulation, mood, and other oestrogen-related functions.

Why Choose Estradot
Estradot patches offer flexible dosing in four strengths (25mcg, 50mcg, 75mcg, and 100mcg), making it easy for clinicians to tailor therapy to the individual. The discreet, transparent patches are small and water-resistant, allowing for convenient, twice-weekly application. The transdermal route reduces gastrointestinal side effects and is generally well tolerated. It’s also considered a lower-risk option for those with mild hepatic impairment or intolerance to oral HRT.

Important Note
Estradot should only be used under medical supervision. It is not suitable for individuals with a history of hormone-sensitive cancers, unexplained vaginal bleeding, active blood clots, or liver dysfunction. Regular reviews and monitoring are essential to ensure the lowest effective dose is used. If you experience leg swelling, chest pain, or sudden vision changes, seek urgent medical attention.