Premarin

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

• Take one tablet daily with or without food

• Swallow whole with water at the same time each day

• Do not skip or discontinue without medical advice

• Store below 25°C

• Keep in original packaging

• Keep out of reach of children

Ingredients

Active Ingredient (per tablet):

• Conjugated oestrogens 0.3mg / 0.625mg / 1.25mg

Other Ingredients:

• Calcium phosphate

• Lactose monohydrate

• Magnesium stearate

• Sucrose

• Colouring agents (may include iron oxides, titanium dioxide)

Side Effects

Common side effects may include:

• Breast tenderness

• Headache

• Nausea

• Vaginal bleeding or discharge

Serious (rare) side effects:

• Blood clots

• Stroke

• Breast cancer

• Liver issues

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not take Premarin if you have a history of hormone-dependent cancer, unexplained vaginal bleeding, blood clots, or liver disease. Not suitable during pregnancy. Only use if your uterus has been removed or alongside a progestogen. Regular medical review is essential.

Premarin Tablets are a form of hormone replacement therapy (HRT) containing conjugated oestrogens. They are used to manage symptoms associated with oestrogen deficiency in postmenopausal women. These include hot flushes, night sweats, vaginal discomfort, and mood disturbances. Premarin is typically prescribed to women who have undergone a hysterectomy or those not requiring a progestogen as part of their HRT regimen.

How It Works
Each Premarin tablet contains a mixture of water-soluble conjugated oestrogens. These are derived from natural sources and mimic the hormonal activity of endogenous oestrogens. The formulation replenishes declining hormone levels, helping to restore hormonal balance. Premarin acts on various target tissues to relieve vasomotor symptoms, maintain vaginal health, and help reduce the risk of bone loss in postmenopausal women.

Why Choose Premarin
Premarin is one of the most established oestrogen-only HRT medications, with multiple strengths available to allow flexible, personalised dosing. It offers effective symptom relief in women who cannot or do not require progestogen supplementation. The oral formulation is easy to administer and suitable for long-term management under medical supervision. Its extensive clinical use and established safety profile make it a preferred option in suitable patients.

Important Note
Premarin is not suitable for women with an intact uterus unless combined with a progestogen. It should not be used by those with a history of hormone-dependent cancers, blood clots, liver disease, or unexplained vaginal bleeding. Before initiating treatment, a full medical assessment is required, and patients must be monitored regularly.