Varenaciline Tablet

How should I take Varenicline?

• Take exactly as prescribed by your doctor, starting one week before your quit date.
• Usually taken once daily for the first 3 days, then increased to twice daily.
• Swallow tablets whole with water, with or without food.
• Complete the full course for best results, usually 12 weeks.

What are the possible side effects?

• Common: nausea, trouble sleeping, abnormal dreams, or headache.
• Less common: mood changes, dizziness, or dry mouth.
• Rare but serious: depression, suicidal thoughts, or severe allergic reactions.

Report any severe mood changes or allergic reactions to a doctor immediately.

What ingredients are in Varenicline Tablets?

• Active ingredient: Varenicline tartrate
• Other ingredients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, magnesium stearate, and film-coating agents (varies by brand).

How should Varenicline Tablets be stored?

• Store below 25°C in a dry place.
• Keep in the original blister packaging to protect from moisture.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the pack.

What is Varenicline?

Varenicline is a prescription-only medication designed to help individuals stop smoking by targeting the neurological processes involved in nicotine addiction. Unlike nicotine replacement therapies (NRT) such as patches, gums, or lozenges, Varenicline does not contain nicotine. Instead, it works by interacting directly with nicotine receptors in the brain—specifically the α4β2 nicotinic acetylcholine receptors. This dual-action effect makes it one of the most effective pharmacological aids available for smoking cessation.

When taken as prescribed, Varenicline binds to the nicotine receptors and stimulates them to a lesser degree than nicotine itself. This partial stimulation helps reduce the cravings and withdrawal symptoms commonly experienced during a quit attempt. At the same time, it blocks nicotine from attaching to these receptors. As a result, if a person does smoke while taking Varenicline, they experience less satisfaction or “reward” from the cigarette, which helps to break the psychological cycle of addiction.

Varenicline is typically taken as part of a structured stop-smoking plan, often alongside behavioural support or counselling. The treatment usually starts around one week before your designated quit date. The dosage begins low and is gradually increased over the first week to allow the body to adjust. Most courses last for 12 weeks, although some patients—particularly those who are successful but still vulnerable to relapse—may continue the treatment for an additional 12 weeks at a maintenance dose.

This medication is suitable for adult smokers who are motivated to quit and have not had success with other cessation methods, including NRT or cold turkey attempts. It is particularly helpful for those who experience intense psychological dependence or strong habitual urges to smoke in certain situations, such as after meals or when stressed.

As with all prescription treatments, Varenicline may not be suitable for everyone. People with a history of seizures, severe kidney problems, or certain mental health conditions should consult their GP to determine if Varenicline is a safe option. Common side effects include nausea, trouble sleeping, and vivid dreams, which often improve after the first couple of weeks of treatment.

When used correctly and with strong commitment, Varenicline significantly increases the chances of quitting smoking for good, offering a valuable non-nicotine alternative to help reclaim long-term health.