Trisequens

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

• Take one tablet daily following the colour-coded sequence

• Swallow whole with water at the same time each day

• Do not take breaks between packs

• Begin new pack immediately after finishing the last

• Store below 25°C

• Keep in original packaging

• Keep out of reach of children

Ingredients

Active Ingredients per tablet:

• Blue tablets: Estradiol 2mg

• White tablets: Estradiol 2mg and Norethisterone acetate 1mg

• Red tablets: Estradiol 1mg and Norethisterone acetate 1mg

Other Ingredients:

• Lactose monohydrate

• Maize starch

• Magnesium stearate

• Hypromellose

• Titanium dioxide

• Colouring agents (specific to tablet colour)

Side Effects

Common side effects may include:

• Headache

• Breast tenderness

• Nausea

• Breakthrough bleeding

Serious (rare) side effects:

• Blood clots

• Stroke or heart attack

• Breast cancer

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not take Trisequens if you have or have had breast cancer, blood clots, liver disease, or unexplained vaginal bleeding. Not suitable during pregnancy. Regular medical reviews are essential to assess ongoing treatment suitability.

Trisequens is a sequential combined hormone replacement therapy (HRT) designed for postmenopausal women who still have a uterus. It effectively treats common menopausal symptoms such as hot flushes, night sweats, mood swings, and vaginal dryness. It is also used to help prevent osteoporosis in women at risk who cannot take other treatments.

How It Works
Trisequens contains two hormones: estradiol (a form of oestrogen) and norethisterone acetate (a synthetic progestogen). The tablets are taken in a specific sequence over 28 days—blue tablets (oestrogen only), white tablets (combined), and red tablets (combined). This phased delivery replenishes declining hormone levels while protecting the endometrium from overgrowth. The sequential regimen closely mimics natural hormonal fluctuations and typically results in monthly withdrawal bleeding.

Why Choose Trisequens
Trisequens is ideal for women who prefer a structured, cyclical HRT plan. The pack design supports clear adherence to the correct sequence. It is particularly helpful in the early stages of menopause when natural hormonal rhythms are still transitioning. With a trusted formulation and proven efficacy, Trisequens supports improved quality of life for women experiencing moderate to severe menopausal symptoms.

Important Note
Trisequens is not suitable for all women. It must not be used in those with a history of hormone-dependent cancers, blood clots, liver disorders, or unexplained vaginal bleeding. Before initiating treatment, a full medical evaluation is necessary. Ongoing review and regular monitoring by your doctor are essential.