Elleste Duet

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

• Take one tablet daily in sequence for 28 days

• Days 1–16: white oestrogen-only tablets

• Days 17–28: grey combined oestrogen and progestogen tablets

• Swallow with water, with or without food

• Start new pack immediately after finishing the previous one

• Store below 25°C

• Keep in original packaging

• Keep out of reach of children

Ingredients

Active Ingredients (Elleste Duet 1 mg and 2 mg):

• White tablets: Estradiol hemihydrate (equivalent to 1 mg or 2 mg estradiol)

• Grey tablets: Estradiol hemihydrate (1 mg or 2 mg) + Norethisterone acetate 1 mg

Other Ingredients:

• Lactose monohydrate

• Maize starch

• Magnesium stearate

• Povidone

• Macrogol

• Hypromellose

• Titanium dioxide

• Iron oxides (for grey tablet colouring)

Side Effects

Common side effects may include:

• Headache

• Nausea

• Breast tenderness

• Vaginal bleeding or spotting

• Mood changes

Serious (rare) side effects:

• Blood clots

• Breast or uterine cancer

• Stroke

• Liver dysfunction

• Allergic reaction

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not use Elleste Duet if you have or have had breast cancer, blood clots, stroke, liver disease, or unexplained vaginal bleeding. Not suitable during pregnancy or while breastfeeding. Use caution in women with high blood pressure, migraines, or diabetes. HRT should be used at the lowest effective dose for the shortest time necessary and reviewed regularly by a healthcare provider.

Elleste Duet is a sequential combined hormone replacement therapy (HRT) designed for postmenopausal women who still have their womb. It is used to relieve symptoms of oestrogen deficiency such as hot flushes, night sweats, mood changes, and vaginal dryness. Elleste Duet is also indicated to help prevent osteoporosis in women at high risk of fractures who are unable to take other forms of bone protection.

How It Works
Elleste Duet contains estradiol, a synthetic version of the body’s natural oestrogen, and norethisterone acetate, a synthetic progestogen. In the first 16 days of each 28-day cycle, estradiol is taken on its own to relieve menopausal symptoms. During the final 12 days, both estradiol and norethisterone are taken together to protect the lining of the womb from the potential risks of unopposed oestrogen, such as endometrial hyperplasia. This sequential regimen mimics the natural hormonal cycle and typically results in a monthly withdrawal bleed.

Why Choose Elleste Duet
Elleste Duet is a well-established, effective HRT option for women seeking symptom relief and uterine protection. The sequential format suits women who prefer a predictable monthly cycle and who have not yet transitioned to continuous combined HRT. Available in both 1 mg and 2 mg oestrogen strengths, it offers flexible dosing to suit individual needs. It helps alleviate a wide range of menopausal symptoms and may support long-term bone health under medical supervision.

Important Note
Elleste Duet should only be used under the supervision of a healthcare provider. It is not a contraceptive and is not suitable during pregnancy or breastfeeding. It should not be used by women with a history of breast cancer, stroke, or active liver disease. Long-term use should be reviewed regularly to ensure continued need and minimise health risks. Unexpected vaginal bleeding or other adverse symptoms should be promptly assessed by a healthcare professional.